Integrative transcription start site analysis and physiological phenotyping reveal torpor-specific expression program in mouse skeletal muscle

Abstract

Ruslan Deviatiiarov et al. identify torpor-specific promoters with an enriched binding motif and the transcription factor ATF3 highly expressed during torpor deprivation. Knocking out Atf3 affected the torpor phenotype, giving rise to molecular targets for studying and translating hypometabolic states.