The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes

Abstract

Background: We analyzed cardiovascular inflammatory (Creactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods: In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = 10 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N = 15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results: Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p< 0.001; B: p< 0.001, C: p< 0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p < 0.001; C: p<0.05, D: p=0.001 pmol/L), respectively, at resolving AHC. However, CRP persisted higher (p< 0.001, p< 0.01), IL-6 lower (p< 0.05, p< 0.001), while homocysteine levels turned out to be similar to controls. Conclusions: AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP.

Keywords

• acute hyperglycemic crisis
• cardiovascular risk markers
• inflammatory markers
• haemostatic markers