Nature Communications (May 2019)
Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
- William W. Greenwald,
- Joshua Chiou,
- Jian Yan,
- Yunjiang Qiu,
- Ning Dai,
- Allen Wang,
- Naoki Nariai,
- Anthony Aylward,
- Jee Yun Han,
- Nikita Kadakia,
- Laura Regue,
- Mei-Lin Okino,
- Frauke Drees,
- Dana Kramer,
- Nicholas Vinckier,
- Liliana Minichiello,
- David Gorkin,
- Joseph Avruch,
- Kelly A. Frazer,
- Maike Sander,
- Bing Ren,
- Kyle J. Gaulton
Affiliations
- William W. Greenwald
- Bioinformatics and Systems Biology Graduate Program
- Joshua Chiou
- Biomedical Sciences Graduate Program
- Jian Yan
- Ludwig Institute for Cancer Research
- Yunjiang Qiu
- Bioinformatics and Systems Biology Graduate Program
- Ning Dai
- Department of Molecular and Cellular Biology, Harvard University
- Allen Wang
- Department of Pediatrics
- Naoki Nariai
- Department of Pediatrics
- Anthony Aylward
- Bioinformatics and Systems Biology Graduate Program
- Jee Yun Han
- Center for Epigenomics
- Nikita Kadakia
- Department of Pediatrics
- Laura Regue
- Department of Molecular and Cellular Biology, Harvard University
- Mei-Lin Okino
- Department of Pediatrics
- Frauke Drees
- Department of Pediatrics
- Dana Kramer
- European Molecular Biology Laboratory, Mouse Biology Unit
- Nicholas Vinckier
- Department of Pediatrics
- Liliana Minichiello
- European Molecular Biology Laboratory, Mouse Biology Unit
- David Gorkin
- Center for Epigenomics
- Joseph Avruch
- Department of Molecular and Cellular Biology, Harvard University
- Kelly A. Frazer
- Department of Pediatrics
- Maike Sander
- Department of Pediatrics
- Bing Ren
- Ludwig Institute for Cancer Research
- Kyle J. Gaulton
- Department of Pediatrics
- DOI
- https://doi.org/10.1038/s41467-019-09975-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes of enhancers and validate IGF2BP2 activity in mouse islets.
