Comparison of nitric oxide levels, roll over test value, and body mass index in preeclampsia and normotension

Abstract

Objective: The study aims to compare levels NO, the ROT, and BMI values in preeclampsia and normotension. Method: This study was an observational analytical study that combined the draft case–control study and a cross-sectional study (hybrid method) conducted in February–June 2020. This study was conducted in the Hospital Dr. Wahidin Sudirohusodo Makasar, Antang Health Center, Barabaraya Health Center, and Mamajang Health Center. Respondents in this study were pregnant women divided into two groups, 108 mothers with normal pregnancies and 42 mothers with preeclampsia. The criteria of the study respondents were single pregnancies, pregnancy of more than 20 weeks, and the gestational age of 20–35 years old. Data collected includes age, parity, gestational age, pregnancy interval, body mass index (BMI), and education. In addition, Nitric oxide levels are determined using Elisa Kit, and roll over test is collected by performing blood pressure measurements at two different positions. Results: The mean serum NO levels in the preeclampsia 176.43 ± 50.8 and 152.75 ± 51.3 in normotension, and there is a meaningful relationship p = 0.012. Mean value of ROT in preeclampsia 23.21 ± 8.54 and 19.63 ± 8.85 in normotension p = 0.026. There is a meaningful difference in IMT with preeclampsia p = 0.003. Conclusion: NO, ROT and BMI are significantly higher in pregnant mothers with preeclampsia than in normal pregnancies.

Keywords

• Nitric oxide
• Roll over test
• Body mass index
• Preeclampsia