Mussel-inspired nanostructured coatings assembled using polydopamine nanoparticles and hydroxyapatite nanorods for biomedical applications

Zhenming Wang; Pengfei Li; Yanan Jiang; Zhanrong Jia; Pengfei Tang; Xiong Lu; Fuzen Ren; Kefeng Wang; Huiping Yuan

doi:10.1016/j.bsbt.2017.01.001

Biosurface and Biotribology (Mar 2017)

Mussel-inspired nanostructured coatings assembled using polydopamine nanoparticles and hydroxyapatite nanorods for biomedical applications

Zhenming Wang,
Pengfei Li,
Yanan Jiang,
Zhanrong Jia,
Pengfei Tang,
Xiong Lu,
Fuzen Ren,
Kefeng Wang,
Huiping Yuan

Affiliations

Zhenming Wang: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Pengfei Li: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Yanan Jiang: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Zhanrong Jia: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Pengfei Tang: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Xiong Lu: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Fuzen Ren: Department of Materials Science and Engineering, South University of Science and Technology, Shenzhen, Guangdong 518055, China
Kefeng Wang: National Engineering Research Center for Biomaterials, Genome Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, China
Huiping Yuan: College of Physical Science and Technology, Sichuan University, Chengdu, Sichuan 610064, China

DOI: https://doi.org/10.1016/j.bsbt.2017.01.001
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 10

Abstract

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Producing hierarchical nanostructured coatings with a biomimetic composition is an effective surface modification strategy to improve the bioactivity of biomaterials. In this study, mussel-inspired polydopamine nanoparticles (PDA-NPs) and hydroxyapatite (HA) nanorods were used to modify Ti surfaces. Firstly, the PDA-NPs were prepared via oxidative self-polymerization of dopamine. Secondly, the HA nanorods were decorated with a PDA nanolayer in order to improve the adhesion of the HA nanorods. Thirdly, the PDA-NPs and PDA-decorated HA nanorods were alternately assembled to form a porous and hierarchical micro/nanostructured {PDA/HA} composite coating on the Ti surfaces. Finally, Bone morphogenetic protein-2 (BMP-2) was immobilized on the {PDA/HA} composite coating using the functional groups of PDA. The BMP-2-loaded {PDA/HA} composite coating exhibited excellent biocompatibility and promoted the adhesion, proliferation, and differentiation of bone marrow stromal cells. The animal implantation tests indicated that the BMP-2-loaded {PDA/HA} composite coating promoted the formation of new bone tissue.

Published in Biosurface and Biotribology

ISSN: 2405-4518 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://ietresearch.onlinelibrary.wiley.com/journal/24054518

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