mSystems
(Aug 2021)
Comprehensive Strain-Level Analysis of the Gut Microbe Faecalibacterium prausnitzii in Patients with Liver Cirrhosis
Yaowen Chen,
Pu Liu,
Runyan Liu,
Shuofeng Hu,
Zhen He,
Guohua Dong,
Chao Feng,
Sijing An,
Xiaomin Ying
Affiliations
Yaowen Chen
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Pu Liu
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Runyan Liu
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Shuofeng Hu
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Zhen He
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Guohua Dong
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Chao Feng
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Sijing An
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
Xiaomin Ying
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China
DOI
https://doi.org/10.1128/mSystems.00775-21
Journal volume & issue
Vol. 6,
no. 4
Abstract
Read online
Most metagenomic studies focus on microbes at the species level, thus ignoring the different effects of different strains of the same species on the host. In this study, we explored the different microbes at the strain level in the intestines of patients with liver cirrhosis and of healthy people.
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