Demonstration of intracellular real-time molecular quantification via FRET-enhanced optical microcavity

Yaping Wang; Marion C. Lang; Jinsong Lu; Mingqian Suo; Mengcong Du; Yubin Hou; Xiu-Hong Wang; Pu Wang

doi:10.1038/s41467-022-34547-4

Nature Communications (Nov 2022)

Demonstration of intracellular real-time molecular quantification via FRET-enhanced optical microcavity

Yaping Wang,
Marion C. Lang,
Jinsong Lu,
Mingqian Suo,
Mengcong Du,
Yubin Hou,
Xiu-Hong Wang,
Pu Wang

Affiliations

Yaping Wang: Laboratory for Biomedical Photonics, Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology
Marion C. Lang: Laboratory for Biomedical Photonics, Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology
Jinsong Lu: Laboratory for Biomedical Photonics, Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology
Mingqian Suo: Laboratory for Biomedical Photonics, Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology
Mengcong Du: Laboratory for Biomedical Photonics, Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology
Yubin Hou: Laboratory for Advanced Laser Technology and Applications, Faculty of Materials and Manufacturing, Beijing University of Technology
Xiu-Hong Wang: Laboratory for Biomedical Photonics, Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology
Pu Wang: Laboratory for Advanced Laser Technology and Applications, Faculty of Materials and Manufacturing, Beijing University of Technology

DOI: https://doi.org/10.1038/s41467-022-34547-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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The authors introduce an active-mode optical microcavity sensor with enhanced sensitivity via Förster resonant energy transfer. Changes in lasing wavelengths of both donor and acceptor enable quantitative molecular analysis and real-time monitoring of intracellular molecules.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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