Drug Design, Development and Therapy (Aug 2021)
Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients
Abstract
Chun-Feng Huang,1,2 Ming-Shi Shiao,3 Tso-Yen Mao2 1Department of Family Medicine, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan, Republic of China; 2Department of Leisure Services Management, Chaoyang University of Technology, Taichung, Taiwan, Republic of China; 3Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan, Republic of ChinaCorrespondence: Tso-Yen MaoDepartment of Leisure Services Management, Chaoyang University of Technology, 168, Jifeng E. Road, Wufeng District, Taichung, 413, Taiwan, Republic of ChinaTel +886 4 23323000 #7453Fax +886 4 23742363Email [email protected]: Several osteoporosis drugs can continuously improve bone mass, but the impact on muscle mass is still unknown. This study aims to investigate how zoledronic acid monotherapy affected muscle mass in osteoporosis patients.Patients and Methods: Patients from an osteoporosis database were divided into two groups in this retrospective cohort, case–control study: zoledronic acid-treated patients (n = 113) and a control group without osteoporosis treatment (n = 118). At four years, appendicular skeletal muscle mass (ASM) and appendicular skeletal muscle mass index (ASMI) were calculated using dual-energy X-ray absorptiometry. The differences in muscle mass between the groups were compared.Results: At baseline, there was no difference in sex, ASM, ASMI, and bone mineral density between the zoledronic acid treatment group and the control group. The treatment group’s skeletal muscle mass increased by 841 g in ASM and 0.35 kg/m2 in ASMI after three years, while decreased in the control group.Conclusion: This study for the first time demonstrated that that zoledronic acid is beneficial not only to the bone but also to muscle.Keywords: muscle mass, osteoporosis, sarcopenia, zoledronic acid
