Communications Biology (May 2022)
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
- Annika Müller-Eigner,
- Adrián Sanz-Moreno,
- Irene de-Diego,
- Anuroop Venkateswaran Venkatasubramani,
- Martina Langhammer,
- Raffaele Gerlini,
- Birgit Rathkolb,
- Antonio Aguilar-Pimentel,
- Tanja Klein-Rodewald,
- Julia Calzada-Wack,
- Lore Becker,
- Sergio Palma-Vera,
- Benedikt Gille,
- Ignasi Forne,
- Axel Imhof,
- Chen Meng,
- Christina Ludwig,
- Franziska Koch,
- John T. Heiker,
- Angela Kuhla,
- Vanessa Caton,
- Julia Brenmoehl,
- Henry Reyer,
- Jennifer Schoen,
- Helmut Fuchs,
- Valerie Gailus-Durner,
- Andreas Hoeflich,
- Martin Hrabe de Angelis,
- Shahaf Peleg
Affiliations
- Annika Müller-Eigner
- Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN)
- Adrián Sanz-Moreno
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Irene de-Diego
- Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN)
- Anuroop Venkateswaran Venkatasubramani
- Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University
- Martina Langhammer
- Institute Genetics and Biometry, Lab Animal Facility, Research Institute for Farm Animal Biology (FBN)
- Raffaele Gerlini
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Birgit Rathkolb
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Antonio Aguilar-Pimentel
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Tanja Klein-Rodewald
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Julia Calzada-Wack
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Lore Becker
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Sergio Palma-Vera
- Institute of Reproductive Biology, Research Institute for Farm Animal Biology (FBN)
- Benedikt Gille
- Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN)
- Ignasi Forne
- Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University
- Axel Imhof
- Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University
- Chen Meng
- Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich
- Christina Ludwig
- Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich
- Franziska Koch
- Institute of Nutritional Physiology, Research Institute for Farm Animal Biology (FBN)
- John T. Heiker
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig
- Angela Kuhla
- Institute for Experimental Surgery, Rostock University Medical Center
- Vanessa Caton
- Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN)
- Julia Brenmoehl
- Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN)
- Henry Reyer
- Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN)
- Jennifer Schoen
- Institute of Reproductive Biology, Research Institute for Farm Animal Biology (FBN)
- Helmut Fuchs
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Valerie Gailus-Durner
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Andreas Hoeflich
- Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN)
- Martin Hrabe de Angelis
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Shahaf Peleg
- Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN)
- DOI
- https://doi.org/10.1038/s42003-022-03339-3
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
This study further characterizes the non-inbred Titan (also known as DU6) mouse line, which could be a useful model for obesity research.
