Understanding the genetic determinants of the brain with MOSTest

Dennis van der Meer; Oleksandr Frei; Tobias Kaufmann; Alexey A. Shadrin; Anna Devor; Olav B. Smeland; Wesley K. Thompson; Chun Chieh Fan; Dominic Holland; Lars T. Westlye; Ole A. Andreassen; Anders M. Dale

doi:10.1038/s41467-020-17368-1

Nature Communications (Jul 2020)

Understanding the genetic determinants of the brain with MOSTest

Dennis van der Meer,
Oleksandr Frei,
Tobias Kaufmann,
Alexey A. Shadrin,
Anna Devor,
Olav B. Smeland,
Wesley K. Thompson,
Chun Chieh Fan,
Dominic Holland,
Lars T. Westlye,
Ole A. Andreassen,
Anders M. Dale

Affiliations

Dennis van der Meer: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Oleksandr Frei: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Tobias Kaufmann: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Alexey A. Shadrin: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Anna Devor: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Olav B. Smeland: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Wesley K. Thompson: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Chun Chieh Fan: Center for Multimodal Imaging and Genetics, University of California at San Diego
Dominic Holland: Departments of Neurosciences and Radiology, University of California at San Diego
Lars T. Westlye: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Ole A. Andreassen: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Anders M. Dale: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo

DOI: https://doi.org/10.1038/s41467-020-17368-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Regional brain morphology has a complex genetic architecture. Here the authors present MOSTest, a multivariate statistical framework, apply it to UK Biobank data, and discover hundreds of loci associated with regional brain morphology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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