Frontiers in Medicine (Jul 2022)

Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir

  • Angioletta Lasagna,
  • Antonio Piralla,
  • Simona Secondino,
  • Paolo Sacchi,
  • Fausto Baldanti,
  • Fausto Baldanti,
  • Raffaele Bruno,
  • Raffaele Bruno,
  • Paolo Pedrazzoli,
  • Paolo Pedrazzoli

DOI
https://doi.org/10.3389/fmed.2022.944855
Journal volume & issue
Vol. 9

Abstract

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Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore, we present the case of a 22-year-old man with relapsed testicular non-seminomatous germ-cell tumor who was diagnosed with COVID-19 during his first auto-HSCT. Our case report is the first one describing the efficacy of early RDV (and its anti-inflammatory effects that might counterbalance the negative effect of the recombinant human granulocyte-colony stimulating factors -rhG-CSF-) in the context of severe neutropenia following HSCT with the concomitant onset of COVID-19.

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