Nature Communications (Mar 2022)
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma
- Xiangjun Liu,
- Shanzhao Jin,
- Simeng Hu,
- Ruoyan Li,
- Haihao Pan,
- Yi Liu,
- Pan Lai,
- Deshu Xu,
- Jingru Sun,
- Ziyang Liu,
- Yumei Gao,
- Yifan Zhao,
- Fengjie Liu,
- Yu Xiao,
- Yingyi Li,
- Yujie Wen,
- Zhuojing Chen,
- Bufang Xu,
- Yuchieh Lin,
- Menglong Ran,
- Qianxi Li,
- Shuxia Yang,
- Hang Li,
- Ping Tu,
- Muzlifah Haniffa,
- Sarah A. Teichmann,
- Fan Bai,
- Yang Wang
Affiliations
- Xiangjun Liu
- Department of Dermatology and Venerology, Peking University First Hospital
- Shanzhao Jin
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Simeng Hu
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Ruoyan Li
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Haihao Pan
- Department of Dermatology and Venerology, Peking University First Hospital
- Yi Liu
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Pan Lai
- Department of Dermatology and Venerology, Peking University First Hospital
- Deshu Xu
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Jingru Sun
- Department of Dermatology and Venerology, Peking University First Hospital
- Ziyang Liu
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Yumei Gao
- Department of Dermatology and Venerology, Peking University First Hospital
- Yifan Zhao
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Fengjie Liu
- Department of Dermatology and Venerology, Peking University First Hospital
- Yu Xiao
- Department of Dermatology and Venerology, Peking University First Hospital
- Yingyi Li
- Department of Dermatology and Venerology, Peking University First Hospital
- Yujie Wen
- Department of Dermatology and Venerology, Peking University First Hospital
- Zhuojing Chen
- Department of Dermatology and Venerology, Peking University First Hospital
- Bufang Xu
- Department of Dermatology and Venerology, Peking University First Hospital
- Yuchieh Lin
- Department of Dermatology and Venerology, Peking University First Hospital
- Menglong Ran
- Department of Dermatology and Venerology, Peking University First Hospital
- Qianxi Li
- Department of Dermatology and Venerology, Peking University First Hospital
- Shuxia Yang
- Department of Dermatology and Venerology, Peking University First Hospital
- Hang Li
- Department of Dermatology and Venerology, Peking University First Hospital
- Ping Tu
- Department of Dermatology and Venerology, Peking University First Hospital
- Muzlifah Haniffa
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Sarah A. Teichmann
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Fan Bai
- Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University
- Yang Wang
- Department of Dermatology and Venerology, Peking University First Hospital
- DOI
- https://doi.org/10.1038/s41467-022-28799-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Cutaneous T cell lymphomas (CTCL) are still poorly characterised at the molecular and single-cell level. Here, the authors analyse CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
