DRESS Syndrome After Lamotrigine Use in A Epilepsy Patient: A Case Report

Abstract

DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome is an acute drug-induced hypersensitivity reaction. DRESS syndrome can cause morbidity and mortality, characterized by fever, skin rash, lymphadenopathy, hematological abnormalities (eosinophilia, atypical lymphocytes), internal (liver or other) organ involvement. Drugs that most commonly cause DRESS syndrome are anticonvulsants, dapsone, sulfonamides, allopurinol and minocycline. Clinical findings usually develop 1-7 weeks after the initiation of the responsible drug, this period may extend up to three months. There are reports stating that the mortality rate reaches up to 10%, and the most important cause of mortality is liver failure. Diagnostic criteria for DRESS syndrome have been established by the RegiSCAR group. In this article, a pediatric case who developed DRESS syndrome after lamotrigine treatment was presented, and the literature on current diagnosis and treatment approaches was reviewed.

Keywords

• anticonvulsant drug
• dress syndrome
• lamotrigine
• antikonvülsan ilaç
• dress sendromu
• lamotrijin