OncoTargets and Therapy (Nov 2020)

Next-Generation Sequencing of Synchronous Multiple Primary Lung Cancers in a Patient with Squamous Cell Carcinoma and Small Cell Lung Cancer

  • Wu X,
  • Huang W,
  • Geng T,
  • Wei Y

Journal volume & issue
Vol. Volume 13
pp. 11621 – 11626

Abstract

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Xinggang Wu,1,2,* Wenhua Huang,3,* Tao Geng,2 Yutao Wei2,4 1Medicine Department, Shihezi University, Shihezi, Xinjiang 832000, People’s Republic of China; 2Cardiothoracic Surgery, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832000, People’s Republic of China; 3Department of Cardiovascular Surgery, Affiliated Central People’s Hospital of Zhanjiang of Guangdong Medical University, Zhanjiang 524045, People’s Republic of China; 4Thoracic Surgery, Jining First People’s Hospital, Jining, Shandong 272000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yutao WeiThoracic Surgery, Jining First People’s Hospital, Cardiothoracic Surgery, The First Affiliated Hospital of Shihezi University School of Medicine, Beier Road, Shihezi 832000, People’s Republic of ChinaTel +86-993-2858456Email [email protected]: The incidence of synchronous multiple primary malignancies is low. The presence of different lung tumor types in one patient is rare. Here, we report a rare case of synchronous lung squamous cell cancer and small cell lung cancer in a 60-year-old man. Because of the presence of two different tumor types, the proper treatment must be determined. To identify treatment targets, the genetic features of primary tumor tissues from the lungs were analyzed by next-generation sequencing (NGS). The objective was to analyze the origin and evolution of multiple primary lung cancers. NGS can find the genetic mutation sites of patients to guide treatment and promote the advancement of precision medicine. The effects of standard treatments were evaluated by response evaluation criteria in solid tumors. The results suggest that early treatment of synchronous multiple primary malignancies is a favorable outcome.Keywords: sMPLC, NGS, chemotherapy, immunotherapy

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