Plasma proteomic data in bipolar II disorders and major depressive disorders
Hyunju Lee,
Sang Jin Rhee,
Jayoun Kim,
Yunna Lee,
Hyeyoung Kim,
Junhee Lee,
Kangeun Lee,
Hyunsuk Shin,
Hyeyoon Kim,
Tae Young Lee,
Minah Kim,
Eun Young Kim,
Se Hyun Kim,
Yong Min Ahn,
Jun Soo Kwon,
Dohyun Han,
Kyooseob Ha
Affiliations
Hyunju Lee
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea
Sang Jin Rhee
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
Jayoun Kim
Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea
Yunna Lee
Department of Neuropsychiatry, Kosin University Gospel Hospital, Busan, Republic of Korea
Hyeyoung Kim
Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea
Junhee Lee
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
Kangeun Lee
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
Hyunsuk Shin
Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
Hyeyoon Kim
Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
Tae Young Lee
Department of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
Minah Kim
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
Eun Young Kim
Mental Health Center, Seoul National University Health Care Center. Department of Human Systems Medicine, Seoul National University College of Medicine
Se Hyun Kim
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
Yong Min Ahn
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Medical Research Center, Institute of Human Behavioral Medicine, Seoul, Republic of Korea
Jun Soo Kwon
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Medical Research Center, Institute of Human Behavioral Medicine, Seoul, Republic of Korea
Dohyun Han
Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul, Republic of Korea; Corresponding author: Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul, Republic of Korea.
Kyooseob Ha
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Medical Research Center, Institute of Human Behavioral Medicine, Seoul, Republic of Korea; Corresponding author at: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
The proteomics data included in this article supplement the research article titled “Predictive protein markers for the severity of depression in mood disorders: A preliminary trans-diagnostic approach study (manuscript ID: JPSYCHIATRES-D-20-00437).” Plasma protein was analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This data article included 370 plasma protein profiles expressed in patients with bipolar II disorder (BD-II) and major depressive disorder (MDD). The tables present the comparison of protein expressions between BD-II and MDD, and the relationship between the severity of the depressive symptoms and protein expression. In addition, details of results adjusting the use of each psychotropic medication (antipsychotics, mood stabilizers, and antidepressants) for 20 proteins that showed a significant relationship with the severity of the depressive symptom were presented in the table. Results of the bioinformatics analysis of proteins, which were significantly related to the severity of depressive symptom, are presented. The blood protein profiles and the results of the analyses presented in this data article provide detailed information on the proteins associated with mood disorders, and could be used as the basis for further mass spectrometry studies in psychiatric disorders.
