Mad1 destabilizes p53 by preventing PML from sequestering MDM2

Jun Wan; Samuel Block; Christina M. Scribano; Rebecca Thiry; Karla Esbona; Anjon Audhya; Beth A. Weaver

doi:10.1038/s41467-019-09471-9

Nature Communications (Apr 2019)

Mad1 destabilizes p53 by preventing PML from sequestering MDM2

Jun Wan,
Samuel Block,
Christina M. Scribano,
Rebecca Thiry,
Karla Esbona,
Anjon Audhya,
Beth A. Weaver

Affiliations

Jun Wan: Department of Cell and Regenerative Biology, University of Wisconsin-Madison
Samuel Block: Department of Biomolecular Chemistry, University of Wisconsin-Madison
Christina M. Scribano: Department of Cell and Regenerative Biology, University of Wisconsin-Madison
Rebecca Thiry: Department of Cell and Regenerative Biology, University of Wisconsin-Madison
Karla Esbona: Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
Anjon Audhya: Department of Biomolecular Chemistry, University of Wisconsin-Madison
Beth A. Weaver: Department of Cell and Regenerative Biology, University of Wisconsin-Madison

DOI: https://doi.org/10.1038/s41467-019-09471-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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