Breast cancer Ki-67 expression prediction by digital breast tomosynthesis radiomics features

Abstract

Abstract Background To investigate whether quantitative radiomic features extracted from digital breast tomosynthesis (DBT) are associated with Ki-67 expression of breast cancer. Materials and methods This is a prospective ethically approved study of 70 women diagnosed with invasive breast cancer in 2018, including 40 low Ki-67 expression (Ki-67 proliferation index 0.5. Conclusion The present study showed that quantitative radiomic imaging features of breast tumour extracted from DBT images are associated with breast cancer Ki-67 expression. Larger studies are needed in order to further evaluate these findings.

Keywords

• Breast neoplasms
• Cell proliferation
• Ki-67 expression
• Mammography
• Radiomics