From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Zi-Wei Zhou; Zi-Wei Zhou; Hui-Zhi Long; Hui-Zhi Long; Yan Cheng; Yan Cheng; Hong-Yu Luo; Hong-Yu Luo; Dan-Dan Wen; Li-Chen Gao; Li-Chen Gao

doi:10.3389/fmicb.2021.767931

Frontiers in Microbiology (Nov 2021)

From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Zi-Wei Zhou,
Zi-Wei Zhou,
Hui-Zhi Long,
Hui-Zhi Long,
Yan Cheng,
Yan Cheng,
Hong-Yu Luo,
Hong-Yu Luo,
Dan-Dan Wen,
Li-Chen Gao,
Li-Chen Gao

Affiliations

Zi-Wei Zhou: Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China
Zi-Wei Zhou: Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China
Hui-Zhi Long: Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China
Hui-Zhi Long: Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China
Yan Cheng: Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China
Yan Cheng: Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China
Hong-Yu Luo: Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China
Hong-Yu Luo: Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China
Dan-Dan Wen: Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China
Li-Chen Gao: Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China
Li-Chen Gao: Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China

DOI: https://doi.org/10.3389/fmicb.2021.767931
Journal volume & issue: Vol. 12

Abstract

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Cervical cancer is the third leading cause of cancer-related death worldwide. Microbes and hosts form a mutually beneficial symbiosis relationship, and various parts of the host body are microbial habitats. Microbes can trigger inflammation in certain parts of the host body, contributing to cervical cancer development. This article reviews the relationship between cervicovaginal microbes, inflammation and cervical cancer, and discusses the effect of some key cervical microbes on cervical cancer. Finally, probiotic therapy and immunotherapy are summarized.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

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