Nature Communications (Aug 2021)

Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord

  • Weipang Chang,
  • Andrea Pedroni,
  • Maria Bertuzzi,
  • Caghan Kizil,
  • András Simon,
  • Konstantinos Ampatzis

DOI
https://doi.org/10.1038/s41467-021-25052-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The mechanisms stimulating adult neurogenesis are unclear. Here, the authors show the contribution of cholinergic and GABAergic signalling within the locomotor network to spinal cord neurogenesis during homeostasis and regeneration, showing neurogenesis depends on circuit activity in the adult zebrafish.