Nature Communications (Mar 2021)
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
- Xiaohui Wang,
- Xiang Lin,
- Zihan Zheng,
- Bingtai Lu,
- Jun Wang,
- Andy Hee-Meng Tan,
- Meng Zhao,
- Jia Tong Loh,
- Sze Wai Ng,
- Qian Chen,
- Fan Xiao,
- Enyu Huang,
- King-Hung Ko,
- Zhong Huang,
- Jingyi Li,
- Kin-Hang Kok,
- Gen Lu,
- Xiaohui Liu,
- Kong-Peng Lam,
- Wanli Liu,
- Yuxia Zhang,
- Kwok-Yung Yuen,
- Tak Wah Mak,
- Liwei Lu
Affiliations
- Xiaohui Wang
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Xiang Lin
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Zihan Zheng
- Chongqing International Institute for Immunology
- Bingtai Lu
- Department of Respiratory Medicine and Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Jun Wang
- Department of Respiratory Medicine and Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Andy Hee-Meng Tan
- Bioprocessing Technology Institute, Agency for Science, Technology and Research
- Meng Zhao
- Ministry of Education Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University
- Jia Tong Loh
- Bioprocessing Technology Institute, Agency for Science, Technology and Research
- Sze Wai Ng
- Bioprocessing Technology Institute, Agency for Science, Technology and Research
- Qian Chen
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Fan Xiao
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Enyu Huang
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- King-Hung Ko
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Zhong Huang
- Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine
- Jingyi Li
- Chongqing International Institute for Immunology
- Kin-Hang Kok
- Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong
- Gen Lu
- Department of Respiratory Medicine and Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Xiaohui Liu
- National Protein Science Facility, Tsinghua University
- Kong-Peng Lam
- Bioprocessing Technology Institute, Agency for Science, Technology and Research
- Wanli Liu
- Ministry of Education Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University
- Yuxia Zhang
- Department of Respiratory Medicine and Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Kwok-Yung Yuen
- Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong
- Tak Wah Mak
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- Liwei Lu
- Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-021-22242-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.
