Frontiers in Neuroscience (Jan 2022)

Assessing the Feasibility of Developing in vivo Neuroprobes for Parallel Intracellular Recording and Stimulation: A Perspective

  • Micha E. Spira,
  • Micha E. Spira,
  • Micha E. Spira,
  • Hadas Erez,
  • Hadas Erez,
  • Aviv Sharon,
  • Aviv Sharon

DOI
https://doi.org/10.3389/fnins.2021.807797
Journal volume & issue
Vol. 15

Abstract

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Developing novel neuroprobes that enable parallel multisite, long-term intracellular recording and stimulation of neurons in freely behaving animals is a neuroscientist’s dream. When fulfilled, it is expected to significantly enhance brain research at fundamental mechanistic levels including that of subthreshold signaling and computations. Here we assess the feasibility of merging the advantages of in vitro vertical nanopillar technologies that support intracellular recordings with contemporary concepts of in vivo extracellular field potential recordings to generate the dream neuroprobes that read the entire electrophysiological signaling repertoire.

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