Modeling of Protein Structures Using Structural Trees

Abstract

This review reports possibilities on the application of inorganics nanoparticles for cancer diagnoses and treatment. The examples of the nanoparticles use as contrast agent for magnetic resonance imaging, fluorescent biomarkers in a microscopy and fluorescent markers in the living tomography of tumour growth are resulted. The prospects of the of the nanoparticles use (on fullerenes example) are considered as fotosensibilizators, generating singlet oxygen. Also note that it may be possible to use gold nanoparticles as heat-producing therapeutic agents for local tumour cells damage, caused by laser warming-up of nanoparticles on a wave-length plazmon resonance. Information is presented about nanoparticles use for drug delivery. At the same time, on own experimental material accumulation nanoparticles in macrophages, litoral cells of the inguinal lymph node and hepatocytes after their introduction in tumors growth area are investigated. The features of tumors metastasize to sentinel lymph nodes and liver after nanoparticles injection are studied.

Keywords

• protein folding
• protein structure comparison
• stereochemical analysis
• structural motifs
• structural similarity