Nature Communications (Aug 2016)
Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates
- Vida Chitsazzadeh,
- Cristian Coarfa,
- Jennifer A. Drummond,
- Tri Nguyen,
- Aaron Joseph,
- Suneel Chilukuri,
- Elizabeth Charpiot,
- Charles H. Adelmann,
- Grace Ching,
- Tran N. Nguyen,
- Courtney Nicholas,
- Valencia D. Thomas,
- Michael Migden,
- Deborah MacFarlane,
- Erika Thompson,
- Jianjun Shen,
- Yoko Takata,
- Kayla McNiece,
- Maxim A. Polansky,
- Hussein A. Abbas,
- Kimal Rajapakshe,
- Adam Gower,
- Avrum Spira,
- Kyle R. Covington,
- Weimin Xiao,
- Preethi Gunaratne,
- Curtis Pickering,
- Mitchell Frederick,
- Jeffrey N. Myers,
- Li Shen,
- Hui Yao,
- Xiaoping Su,
- Ronald P. Rapini,
- David A. Wheeler,
- Ernest T. Hawk,
- Elsa R. Flores,
- Kenneth Y. Tsai
Affiliations
- Vida Chitsazzadeh
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center Houston
- Cristian Coarfa
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Jennifer A. Drummond
- Human Genome Sequencing Center, Baylor College of Medicine
- Tri Nguyen
- Northwest Diagnostic Clinic
- Aaron Joseph
- Skin and Laser Surgery Associates
- Suneel Chilukuri
- Bellaire Dermatology
- Elizabeth Charpiot
- Bellaire Dermatology
- Charles H. Adelmann
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center Houston
- Grace Ching
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center Houston
- Tran N. Nguyen
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center Houston
- Courtney Nicholas
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center Houston
- Valencia D. Thomas
- Department of Dermatology, University of Texas MD Anderson Cancer Center Houston
- Michael Migden
- Department of Dermatology, University of Texas MD Anderson Cancer Center Houston
- Deborah MacFarlane
- Department of Dermatology, University of Texas MD Anderson Cancer Center Houston
- Erika Thompson
- Sequencing and Microarray Facility, University of Texas MD Anderson Cancer Center Houston,
- Jianjun Shen
- Next Generation Sequencing Facility, Smithville, University of Texas MD Anderson Cancer Center Houston,
- Yoko Takata
- Next Generation Sequencing Facility, Smithville, University of Texas MD Anderson Cancer Center Houston,
- Kayla McNiece
- Department of Dermatology, University of Texas Medical School at Houston
- Maxim A. Polansky
- Department of Dermatology, University of Texas Medical School at Houston
- Hussein A. Abbas
- Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center Houston
- Kimal Rajapakshe
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Adam Gower
- Department of Medicine, Boston University School of Medicine
- Avrum Spira
- Department of Medicine, Boston University School of Medicine
- Kyle R. Covington
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Weimin Xiao
- Department of Biology and Biochemistry University of Houston
- Preethi Gunaratne
- Department of Biology and Biochemistry University of Houston
- Curtis Pickering
- Department of Head & Neck Surgery, University of Texas MD Anderson Cancer Center Houston
- Mitchell Frederick
- Department of Head & Neck Surgery, University of Texas MD Anderson Cancer Center Houston
- Jeffrey N. Myers
- Department of Head & Neck Surgery, University of Texas MD Anderson Cancer Center Houston
- Li Shen
- Department of Bioinformatics & Computational Biology, University of Texas MD Anderson Cancer Center Houston
- Hui Yao
- Department of Bioinformatics & Computational Biology, University of Texas MD Anderson Cancer Center Houston
- Xiaoping Su
- Department of Bioinformatics & Computational Biology, University of Texas MD Anderson Cancer Center Houston
- Ronald P. Rapini
- Department of Dermatology, University of Texas MD Anderson Cancer Center Houston
- David A. Wheeler
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Ernest T. Hawk
- Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center Houston
- Elsa R. Flores
- Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center Houston
- Kenneth Y. Tsai
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center Houston
- DOI
- https://doi.org/10.1038/ncomms12601
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.
