Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells

• Laween Uthman,
• Anna Homayr,
• Rio P. Juni,
• Eva L. Spin,
• Raphaela Kerindongo,
• Marleen Boomsma,
• Markus W. Hollmann,
• Benedikt Preckel,
• Pieter Koolwijk,
• Victor W.M. van Hinsbergh,
• Coert J. Zuurbier,
• Martin Albrecht,
• Nina C. Weber

Affiliations

Laween Uthman

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Anna Homayr

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands; Department of Anesthesiology and Intensive Care Medicine, UKSH, Campus Kiel, Kiel, Germany

Rio P. Juni

Department of Physiology, Amsterdam UMC, location VU medical center (VUMC), VU University, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Eva L. Spin

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Raphaela Kerindongo

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Marleen Boomsma

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Markus W. Hollmann

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Benedikt Preckel

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Pieter Koolwijk

Department of Physiology, Amsterdam UMC, location VU medical center (VUMC), VU University, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Victor W.M. van Hinsbergh

Department of Physiology, Amsterdam UMC, location VU medical center (VUMC), VU University, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Coert J. Zuurbier

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands

Martin Albrecht

Department of Anesthesiology and Intensive Care Medicine, UKSH, Campus Kiel, Kiel, Germany

Nina C. Weber

Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Amsterdam UMC, location Academic Medical Centre (AMC), University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands