Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Abstract

Breast cancer has the highest incidence and is the fifth leading cause of death in women worldwide. Cancer formation is a multistep, multistep process involving cellular and molecular events. At all its stages, in an initially healthy single cell, there is a gradual accumulation of genetic changes in DNA caused by endogenous and exogenous factors. Breast cancer-predisposing mutations are not evenly distributed among populations, and each ethnic group is descended from its own pool of ancestors who carried a unique spectrum of alleles associated with the disease, making it imperative that studies of this kind be conducted to identify “population-specific markers.”