CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT

Mohamed F. Mohamed; Kajal Gupta; Josef W. Goldufsky; Ruchi Roy; Lauren T. Callaghan; Dawn M. Wetzel; Timothy M. Kuzel; Jochen Reiser; Sasha H. Shafikhani

doi:10.1038/s41467-022-28967-5

Nature Communications (Mar 2022)

CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT

Mohamed F. Mohamed,
Kajal Gupta,
Josef W. Goldufsky,
Ruchi Roy,
Lauren T. Callaghan,
Dawn M. Wetzel,
Timothy M. Kuzel,
Jochen Reiser,
Sasha H. Shafikhani

Affiliations

Mohamed F. Mohamed: Department of Medicine, Rush University Medical Center
Kajal Gupta: Department of Medicine, Rush University Medical Center
Josef W. Goldufsky: Department of Medicine, Rush University Medical Center
Ruchi Roy: Department of Medicine, Rush University Medical Center
Lauren T. Callaghan: Department of Pediatrics, University of Texas Southwestern Medical Center
Dawn M. Wetzel: Department of Pediatrics, University of Texas Southwestern Medical Center
Timothy M. Kuzel: Department of Medicine, Rush University Medical Center
Jochen Reiser: Department of Medicine, Rush University Medical Center
Sasha H. Shafikhani: Department of Medicine, Rush University Medical Center

DOI: https://doi.org/10.1038/s41467-022-28967-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Pseudomonas aeruginosa secretes the toxin ExoT, which is important for pathogenesis. Here, the authors show that ExoT inhibits NLRC4-dependent inflammatory responses during wound infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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