Journal of Clinical Medicine (Feb 2022)
Consensus on COVID-19 Vaccination in Pediatric Oncohematological Patients, on Behalf of Infectious Working Group of Italian Association of Pediatric Hematology Oncology
- Simone Cesaro,
- Paola Muggeo,
- Daniele Zama,
- Monica Cellini,
- Katia Perruccio,
- Antonella Colombini,
- Francesca Carraro,
- Maria Grazia Petris,
- Valeria Petroni,
- Maurizio Mascarin,
- Francesco Baccelli,
- Elena Soncini,
- Rosamaria Mura,
- Milena La Spina,
- Nunzia Decembrino,
- Roberta Burnelli,
- Stefano Frenos,
- Elio Castagnola,
- Maura Faraci,
- Cristina Meazza,
- Federica Barzaghi,
- Maria Rosaria D’Amico,
- Maria Capasso,
- Elisabetta Calore,
- Ottavio Ziino,
- Angelica Barone,
- Francesca Compagno,
- Laura Luti,
- Federica Galaverna,
- Raffaella De Santis,
- Letizia Brescia,
- Linda Meneghello,
- Angelamaria Petrone,
- Nagua Giurici,
- Daniela Onofrillo,
- Fabian Schumacher,
- Federico Mercolini
Affiliations
- Simone Cesaro
- Pediatric Hematology Oncology Unit, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, 37100 Verona, Italy
- Paola Muggeo
- Pediatric Oncology-Hematology Unit, Department of Pediatrics, Azienda Ospedaliero Universitria Policlinico, 70120 Bari, Italy
- Daniele Zama
- Pediatric Oncology and Hematology Unit “Lalla Seràgnoli”, Pediatric Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliero-Universitaria di Bologna, 40100 Bologna, Italy
- Monica Cellini
- Pediatric Oncology-Hematology Unit, Modena University Hospital, 41100 Modena, Italy
- Katia Perruccio
- Pediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, 06100 Perugia, Italy
- Antonella Colombini
- Department of Pediatrics, Ospedale San Gerardo, University of Milano-Bicocca, 20900 Monza, Italy
- Francesca Carraro
- Division of Paediatric Onco-Haematology, Stem Cell Transplantation and Cellular Therapy, Città della Salute e della Scienza Hospital, 10100 Turin, Italy
- Maria Grazia Petris
- Hematology Oncology Division, Department of Women’s and Children’s Health, University of Padova, 35100 Padova, Italy
- Valeria Petroni
- Division of Pediatric Hematology and Oncology, Ospedale G. Salesi, 60100 Ancona, Italy
- Maurizio Mascarin
- Adolescent and Young Adult Oncology and Pediatric Radiotherapy Unit, CRO–Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy
- Francesco Baccelli
- Pediatric Oncology and Hematology Unit “Lalla Seràgnoli”, Pediatric Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliero-Universitaria di Bologna, 40100 Bologna, Italy
- Elena Soncini
- Pediatric Oncohematology and Bone Marrow Transplant Unit, Children’s Hospital, Spedali Civili, 25100 Brescia, Italy
- Rosamaria Mura
- Pediatric Oncology Unit, Azienda Ospedaliera Brotzu, 09100 Cagliari, Italy
- Milena La Spina
- Pediatric Hematology and Oncology Unit—AOU Policlinico “Rodolico-San Marco“, University of Catania, 95100 Catania, Italy
- Nunzia Decembrino
- Pediatric Hematology and Oncology Unit—AOU Policlinico “Rodolico-San Marco“, University of Catania, 95100 Catania, Italy
- Roberta Burnelli
- Pediatric Onco-Hematology Unit, Sant’Anna Hospital, 44100 Ferrara, Italy
- Stefano Frenos
- Division of Pediatric Oncology/Hematology, Meyer University Children’s Hospital, 50100 Florence, Italy
- Elio Castagnola
- Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Giannina Gaslini, 16100 Genova, Italy
- Maura Faraci
- Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Giannina Gaslini, 16100 Genova, Italy
- Cristina Meazza
- Pediatric Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20100 Milan, Italy
- Federica Barzaghi
- Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, 20100 Milan, Italy
- Maria Rosaria D’Amico
- Department of Pediatric Hemato-Oncology, AORN Santobono-Pausilipon, 80100 Naples, Italy
- Maria Capasso
- Department of Pediatric Hemato-Oncology, AORN Santobono-Pausilipon, 80100 Naples, Italy
- Elisabetta Calore
- Hematology Oncology Division, Department of Women’s and Children’s Health, University of Padova, 35100 Padova, Italy
- Ottavio Ziino
- Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, 90100 Palermo, Italy
- Angelica Barone
- Pediatric Onco-Hematology Unit, Pediatric Clinic, Pietro Barilla Children’s Hospital, University of Parma, 43100 Parma, Italy
- Francesca Compagno
- Pediatric Hematology/Oncology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
- Laura Luti
- Pediatric Onco-Hematology Unit, Pisa University Hospital, 56100 Pisa, Italy
- Federica Galaverna
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00100 Rome, Italy
- Raffaella De Santis
- Hemato-Oncology Unit, Department of Pediatrics, ‘Casa Sollievo della Sofferenza’ Hospital, 71013 San Giovanni Rotondo, Italy
- Letizia Brescia
- Hemato-Oncology Unit, SS. Annunziata Hospital, 74100 Taranto, Italy
- Linda Meneghello
- U.O.M. Pediatria Ospedale S. Chiara, 38100 Trento, Italy
- Angelamaria Petrone
- U.O.M. Pediatria Ospedale S. Chiara, 38100 Trento, Italy
- Nagua Giurici
- Pediatric Hematology-Oncology, Institute for Maternal and Child Health IRCCS “Burlo Garofolo”, 34100 Trieste, Italy
- Daniela Onofrillo
- Paediatric Haemato-Oncology Unit, Hematology Department, Hospital of Pescara, 65100 Pescara, Italy
- Fabian Schumacher
- Pediatric Oncohematology and Bone Marrow Transplant Unit, Children’s Hospital, Spedali Civili, 25100 Brescia, Italy
- Federico Mercolini
- Pediatric Onco-Hematology Unit, Department of Pediatrics, Hospital of Bolzano, 39100 Bolzano, Italy
- DOI
- https://doi.org/10.3390/jcm11051235
- Journal volume & issue
-
Vol. 11,
no. 5
p. 1235
Abstract
Vaccines represent the best tool to prevent the severity course and fatal consequences of the pandemic by the new Coronavirus 2019 infection (SARS-CoV-2). Considering the limited data on vaccination of pediatric oncohematological patients, we developed a Consensus document to support the Italian pediatric hematological oncological (AIEOP) centers in a scientifically correct communication with families and patients and to promote vaccination. The topics of the Consensus were: SARS-CoV-2 infection and disease (COVID-19) in the pediatric subjects; COVID-19 vaccines (type, schedule); who and when to vaccinate; contraindications and risk of serious adverse events; rare adverse events; third dose and vaccination after COVID-19; and other general prevention measures. Using the Delphi methodology for Consensus, 21 statements and their corresponding rationale were elaborated and discussed with the representatives of 31 centers, followed by voting. A high grade of Consensus was obtained on topics such as the potential risk of severe COVID-19 outcome in pediatric oncohematological patients, the need for vaccination as a preventative measure, the type, schedule and booster dose of vaccine, the eligibility of the patients for vaccination, and the timing, definition, and management of contraindications and serious adverse events, and other general prevention measures. All 21 of the statements were approved. This consensus document highlights that children and adolescents affected by hematological and oncological diseases are a fragile category. Vaccination plays an important role to prevent COVID-19, to permit the regular administration of chemotherapy or other treatments, to perform control visits and hospital admissions, and to prevent treatment delays.
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