JACC: Basic to Translational Science (Jun 2019)
Western Diet-Fed, Aortic-Banded Ossabaw Swine
- T. Dylan Olver, PhD,
- Jenna C. Edwards, BS,
- Thomas J. Jurrissen, BS,
- Adam B. Veteto, MS,
- John L. Jones, MS,
- Chen Gao, BS,
- Christoph Rau, PhD,
- Chad M. Warren, MS,
- Paula J. Klutho, PhD,
- Linda Alex, PhD,
- Stephanie C. Ferreira-Nichols, BS,
- Jan R. Ivey, BS,
- Pamela K. Thorne, MS,
- Kerry S. McDonald, PhD,
- Maike Krenz, MD,
- Christopher P. Baines, PhD,
- R. John Solaro, PhD,
- Yibin Wang, PhD,
- David A. Ford, PhD,
- Timothy L. Domeier, PhD,
- Jaume Padilla, PhD,
- R. Scott Rector, PhD,
- Craig A. Emter, PhD
Affiliations
- T. Dylan Olver, PhD
- Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri
- Jenna C. Edwards, BS
- Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri
- Thomas J. Jurrissen, BS
- Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri
- Adam B. Veteto, MS
- Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri
- John L. Jones, MS
- Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri
- Chen Gao, BS
- David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
- Christoph Rau, PhD
- David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
- Chad M. Warren, MS
- Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois
- Paula J. Klutho, PhD
- Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri
- Linda Alex, PhD
- Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri
- Stephanie C. Ferreira-Nichols, BS
- Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri
- Jan R. Ivey, BS
- Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri
- Pamela K. Thorne, MS
- Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri
- Kerry S. McDonald, PhD
- Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri
- Maike Krenz, MD
- Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri; Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri
- Christopher P. Baines, PhD
- Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri; Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri; Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri
- R. John Solaro, PhD
- Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois
- Yibin Wang, PhD
- David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
- David A. Ford, PhD
- Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University- School of Medicine, St. Louis, Missouri
- Timothy L. Domeier, PhD
- Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri; Address for correspondence: Dr. Craig A. Emter, Dr. R. Scott Rector, Dr. Jaume Padilla, and Dr. Timothy L. Domeier, University of Missouri-Columbia, 1600 East Rollins, Columbia, Missouri 65211.
- Jaume Padilla, PhD
- Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri; Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri; Department of Child Health, University of Missouri-Columbia, Columbia, Missouri; Address for correspondence: Dr. Craig A. Emter, Dr. R. Scott Rector, Dr. Jaume Padilla, and Dr. Timothy L. Domeier, University of Missouri-Columbia, 1600 East Rollins, Columbia, Missouri 65211.
- R. Scott Rector, PhD
- Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri; Department of Medicine – University of Missouri-Columbia, Columbia, Missouri; Research Service, Harry S Truman Memorial VA Hospital, University of Missouri-Columbia, Columbia, Missouri; Address for correspondence: Dr. Craig A. Emter, Dr. R. Scott Rector, Dr. Jaume Padilla, and Dr. Timothy L. Domeier, University of Missouri-Columbia, 1600 East Rollins, Columbia, Missouri 65211.
- Craig A. Emter, PhD
- Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri; Address for correspondence: Dr. Craig A. Emter, Dr. R. Scott Rector, Dr. Jaume Padilla, and Dr. Timothy L. Domeier, University of Missouri-Columbia, 1600 East Rollins, Columbia, Missouri 65211.
- Journal volume & issue
-
Vol. 4,
no. 3
pp. 404 – 421
Abstract
Summary: The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet−fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF. Key Words: cardio-metabolic disease, heart failure, integrative pathophysiology, preclinical model of cardiovascular disease
