Nature Communications (Apr 2018)
Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
Abstract
The transcription factor Srf is a central regulator of immediate-early and actin cytoskeletal genes. Here the authors show that Srf is activated by repression of β-actin, promoting iPSC reprogramming of neural progenitor cells and hepatoblasts by repressing cell-type specific genes.