Nature Communications (May 2021)
IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella
- Qiubin Lin,
- Li Rong,
- Xian Jia,
- Renhao Li,
- Bin Yu,
- Jingchu Hu,
- Xiao Luo,
- S. R. Badea,
- Chen Xu,
- Guofeng Fu,
- Kejiong Lai,
- Ming-chun Lee,
- Baozhong Zhang,
- Huarui Gong,
- Nan Zhou,
- Xiao Lei Chen,
- Shu-hai Lin,
- Guo Fu,
- Jian-Dong Huang
Affiliations
- Qiubin Lin
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Li Rong
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Xian Jia
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Medicine, Xiamen University
- Renhao Li
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Bin Yu
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jingchu Hu
- Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Xiao Luo
- Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- S. R. Badea
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chen Xu
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Guofeng Fu
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Medicine, Xiamen University
- Kejiong Lai
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Medicine, Xiamen University
- Ming-chun Lee
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Baozhong Zhang
- Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Huarui Gong
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Nan Zhou
- Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Xiao Lei Chen
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Medicine, Xiamen University
- Shu-hai Lin
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Medicine, Xiamen University
- Guo Fu
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Medicine, Xiamen University
- Jian-Dong Huang
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-021-22755-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Cancer metastasis is one of the major causes of cancer related deaths and there is an urgent need to find more clinically effective metastasis targeting agents. Here, the authors show that Salmonella YB1 inhibits metastasis in multiple mouse models of cancer through a mechanism dependent on IFN-γ and NK cells.
