CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis

Yan Xi; Niu Yinghao; Wang Yaojie; Wei Sisi; Han Lina; Guo Zhongyu; Zhao Lianmei; Gao Feng

doi:10.1515/med-2024-1100

Open Medicine (Jan 2025)

CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis

Yan Xi,
Niu Yinghao,
Wang Yaojie,
Wei Sisi,
Han Lina,
Guo Zhongyu,
Zhao Lianmei,
Gao Feng

Affiliations

Yan Xi: Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
Niu Yinghao: Department of Clinical Biobank, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China
Wang Yaojie: Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
Wei Sisi: Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
Han Lina: Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
Guo Zhongyu: Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
Zhao Lianmei: Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
Gao Feng: Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China

DOI: https://doi.org/10.1515/med-2024-1100
Journal volume & issue: Vol. 20, no. 1
pp. 11193 – 205

Abstract

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This study aims to investigate the role and mechanism of p-hydroxyl cinnamaldehyde (CMSP) in triggering ferroptosis of small cell lung cancer (SCLC) cells.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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