Epithelial tension in the second heart field promotes mouse heart tube elongation

Alexandre Francou; Christopher De Bono; Robert G. Kelly

doi:10.1038/ncomms14770

Nature Communications (Mar 2017)

Epithelial tension in the second heart field promotes mouse heart tube elongation

Alexandre Francou,
Christopher De Bono,
Robert G. Kelly

Affiliations

Alexandre Francou: Aix-Marseille University, CNRS UMR 7288, Developmental Biology Institute of Marseille
Christopher De Bono: Aix-Marseille University, CNRS UMR 7288, Developmental Biology Institute of Marseille
Robert G. Kelly: Aix-Marseille University, CNRS UMR 7288, Developmental Biology Institute of Marseille

DOI: https://doi.org/10.1038/ncomms14770
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Epithelial progenitor cell growth in the second heart field contributes to heart morphogenesis but how this is regulated at the tissue level is unclear. Here, the authors show that cell elongation, polarized actomyosin and nuclear YAP/TAZ drive epithelial growth and correlate with mechanical tension.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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