Cells
(May 2019)
Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
Nadia Marascio,
Maria Mazzitelli,
Grazia Pavia,
Aida Giancotti,
Giorgio Settimo Barreca,
Chiara Costa,
Vincenzo Pisani,
Giuseppe Greco,
Francesca Serapide,
Enrico Maria Trecarichi,
Francesco Casalinuovo,
Maria Carla Liberto,
Giovanni Matera,
Carlo Torti
Affiliations
Nadia Marascio
Department of Health Sciences, Unit of Clinical Microbiology, “Magna Graecia” University, 88100 Catanzaro, Italy
Maria Mazzitelli
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
Grazia Pavia
Department of Health Sciences, Unit of Clinical Microbiology, “Magna Graecia” University, 88100 Catanzaro, Italy
Aida Giancotti
Department of Health Sciences, Unit of Clinical Microbiology, “Magna Graecia” University, 88100 Catanzaro, Italy
Giorgio Settimo Barreca
Department of Health Sciences, Unit of Clinical Microbiology, “Magna Graecia” University, 88100 Catanzaro, Italy
Chiara Costa
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
Vincenzo Pisani
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
Giuseppe Greco
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
Francesca Serapide
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
Enrico Maria Trecarichi
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
Francesco Casalinuovo
Institute for Experimental Veterinary Medicine of Southern Italy, 88100 Catanzaro, Italy
Maria Carla Liberto
Department of Health Sciences, Unit of Clinical Microbiology, “Magna Graecia” University, 88100 Catanzaro, Italy
Giovanni Matera
Department of Health Sciences, Unit of Clinical Microbiology, “Magna Graecia” University, 88100 Catanzaro, Italy
Carlo Torti
Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, “Magna Graecia” University, 88100 Catanzaro, Italy
DOI
https://doi.org/10.3390/cells8050416
Journal volume & issue
Vol. 8,
no. 5
Abstract
Read online
Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a sustained virological response (SVR) in more than 90% of adult patients. At present, clinical trials are ongoing and real-life data are still limited in children. Herein, we report two cases of pediatric patients treated with fixed-dose combination of sofosbuvir/ledipasvir, already approved to treat HCV4 genotype. Both young girls achieved SVR even though HCV4 isolates carried L28M and M31L NS5A resistance-associated substitutions (RASs). Therefore, possible effects of these RASs merit further study, especially in children.
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