Bioengineering (Apr 2021)

CoreValve vs. Sapien 3 Transcatheter Aortic Valve Replacement: A Finite Element Analysis Study

  • Francesco Nappi,
  • Laura Mazzocchi,
  • Cristiano Spadaccio,
  • David Attias,
  • Irina Timofeva,
  • Laurent Macron,
  • Adelaide Iervolino,
  • Simone Morganti,
  • Ferdinando Auricchio

DOI
https://doi.org/10.3390/bioengineering8050052
Journal volume & issue
Vol. 8, no. 5
p. 52

Abstract

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Aim: to investigate the factors implied in the development of postoperative complications in both self-expandable and balloon-expandable transcatheter heart valves by means of finite element analysis (FEA). Materials and methods: FEA was integrated into CT scans to investigate two cases of postoperative device failure for valve thrombosis after the successful implantation of a CoreValve and a Sapien 3 valve. Data were then compared with two patients who had undergone uncomplicated transcatheter heart valve replacement (TAVR) with the same types of valves. Results: Computational biomechanical modeling showed calcifications persisting after device expansion, not visible on the CT scan. These calcifications determined geometrical distortion and elliptical deformation of the valve predisposing to hemodynamic disturbances and potential thrombosis. Increased regional stress was also identified in correspondence to the areas of distortion with the associated paravalvular leak. Conclusion: the use of FEA as an adjunct to preoperative imaging might assist patient selection and procedure planning as well as help in the detection and prevention of TAVR complications.

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