Frontiers in Bioengineering and Biotechnology (Jul 2022)

Role of chitosan in titanium coatings. trends and new generations of coatings

  • Nansi López-Valverde,
  • Javier Aragoneses,
  • Antonio López-Valverde,
  • Cinthia Rodríguez,
  • Bruno Macedo de Sousa,
  • Juan Manuel Aragoneses

DOI
https://doi.org/10.3389/fbioe.2022.907589
Journal volume & issue
Vol. 10

Abstract

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Survival studies of dental implants currently reach high figures. However, considering that the recipients are middle-aged individuals with associated pathologies, research is focused on achieving bioactive surfaces that ensure osseointegration. Chitosan is a biocompatible, degradable polysaccharide with antimicrobial and anti-inflammatory properties, capable of inducing increased growth and fixation of osteoblasts around chitosan-coated titanium. Certain chemical modifications to its structure have been shown to enhance its antibacterial activity and osteoinductive properties and it is generally believed that chitosan-coated dental implants may have enhanced osseointegration capabilities and are likely to become a commercial option in the future. Our review provided an overview of the current concepts and theories of osseointegration and current titanium dental implant surfaces and coatings, with a special focus on the in vivo investigation of chitosan-coated implants and a current perspective on the future of titanium dental implant coatings.

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