Nature Communications (Oct 2021)
High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes
Abstract
The authors demonstrate a colourimetric imaging method using plasmonic nanoparticles for visualisation of heterochromatin histone markers. Based on the distance-dependent coupling effect, resulting in spectral shifts, they observe reorganisation of histone markers caused by oncogene-induced senescence.