Nature Communications (Oct 2021)

High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes

  • Hyun Ji An,
  • Yun Kim,
  • Soojeong Chang,
  • Hakchun Kim,
  • Jihwan Song,
  • Hyunsung Park,
  • Inhee Choi

DOI
https://doi.org/10.1038/s41467-021-26224-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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The authors demonstrate a colourimetric imaging method using plasmonic nanoparticles for visualisation of heterochromatin histone markers. Based on the distance-dependent coupling effect, resulting in spectral shifts, they observe reorganisation of histone markers caused by oncogene-induced senescence.