A Case of Lung Adenocarcinoma Harboring a Rare LOC285000-ALK-NCK2 Gene Fusion Identified by Next-Generation Sequencing With Long-Term Response to Crizotinib

Min Zhang, MBBS; Huan Zhou, MM; Dan Liu, MD, PhD; Ruoying Yu, MD, PhD; Jun Chen, MD, PhD

JTO Clinical and Research Reports (Feb 2021)

A Case of Lung Adenocarcinoma Harboring a Rare LOC285000-ALK-NCK2 Gene Fusion Identified by Next-Generation Sequencing With Long-Term Response to Crizotinib

Min Zhang, MBBS,
Huan Zhou, MM,
Dan Liu, MD, PhD,
Ruoying Yu, MD, PhD,
Jun Chen, MD, PhD

Affiliations

Min Zhang, MBBS: Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, People’s Republic of China
Huan Zhou, MM: Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, People’s Republic of China
Dan Liu, MD, PhD: Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, People’s Republic of China
Ruoying Yu, MD, PhD: Department of Research and Development, Translational Medicine Research Institute, Geneseeq Technology Inc., Toronto, Ontario, Canada
Jun Chen, MD, PhD: Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, People’s Republic of China; Corresponding author. Address for correspondence: Jun Chen, MD, PhD, Department of Oncology, The Second Hospital of Dalian Medical University, 467th Zhongshan Rd., Shahekou District, Dalian City 116023, Liaoning, People’s Republic of China.

Journal volume & issue: Vol. 2, no. 2
p. 100106

Abstract

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Most patients with NSCLC, initially sensitive, will develop resistance after a period of time after the application of ALK inhibitors. We present here a rare LOC285000-ALK-NCK2 gene fusion with response to crizotinib treatment; the patient achieved a progression-free survival of 23 months.

Published in JTO Clinical and Research Reports

ISSN: 2666-3643 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/jto-clinical-and-research-reports/

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