Nature Communications (Oct 2016)

Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization

  • Marjolein B. M. Meddens,
  • Elvis Pandzic,
  • Johan A. Slotman,
  • Dominique Guillet,
  • Ben Joosten,
  • Svenja Mennens,
  • Laurent M. Paardekooper,
  • Adriaan B. Houtsmuller,
  • Koen van den Dries,
  • Paul W. Wiseman,
  • Alessandra Cambi

DOI
https://doi.org/10.1038/ncomms13127
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 17

Abstract

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Podosomes are adhesive cytoskeletal structures found in several cell types, but whether or how they are interconnected is not known. Here the authors demonstrate mesoscale connectivity of podosome clusters by imaging directional flow patterns of podosome components vinculin, talin and F-actin.