The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes

Derek R. Case; Jon Zubieta; Robert P. Doyle

doi:10.3390/molecules25143172

Molecules (Jul 2020)

The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes

Derek R. Case,
Jon Zubieta,
Robert P. Doyle

Affiliations

Derek R. Case: Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA
Jon Zubieta: Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA
Robert P. Doyle: Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA

DOI: https://doi.org/10.3390/molecules25143172
Journal volume & issue: Vol. 25, no. 14
p. 3172

Abstract

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The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease—predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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