Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Qian Luo; Honghu Li; Wei Shan; Cong Wei; Yan Long; Shuyang Cai; Xiangjun Zeng; Xue Li; Yulin Xu; Xiaoxiao Xu; Yi Luo; Pengxu Qian; He Huang

doi:10.1155/2021/9919422

Stem Cells International (Jan 2021)

Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Qian Luo,
Honghu Li,
Wei Shan,
Cong Wei,
Yan Long,
Shuyang Cai,
Xiangjun Zeng,
Xue Li,
Yulin Xu,
Xiaoxiao Xu,
Yi Luo,
Pengxu Qian,
He Huang

Affiliations

Qian Luo: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Honghu Li: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Wei Shan: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Cong Wei: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Yan Long: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Shuyang Cai: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Xiangjun Zeng: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Xue Li: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Yulin Xu: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Xiaoxiao Xu: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Yi Luo: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
Pengxu Qian: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China
He Huang: BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China

DOI: https://doi.org/10.1155/2021/9919422
Journal volume & issue: Vol. 2021

Abstract

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Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications.

Published in Stem Cells International

ISSN: 1687-966X (Print); 1687-9678 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine
Website: https://onlinelibrary.wiley.com/journal/4162

About the journal