Nature Communications (Sep 2021)
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
- Marco Heestermans,
- Clément Naudin,
- Reiner K. Mailer,
- Sandra Konrath,
- Kristin Klaetschke,
- Anne Jämsä,
- Maike Frye,
- Carsten Deppermann,
- Giordano Pula,
- Piotr Kuta,
- Manuel A. Friese,
- Mathias Gelderblom,
- Albert Sickmann,
- Roger J. S. Preston,
- Jerzy-Roch Nofer,
- Stefan Rose-John,
- Lynn M. Butler,
- Ophira Salomon,
- Evi X. Stavrou,
- Thomas Renné
Affiliations
- Marco Heestermans
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Clément Naudin
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Reiner K. Mailer
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Sandra Konrath
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Kristin Klaetschke
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Anne Jämsä
- Karolinska University Hospital
- Maike Frye
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Carsten Deppermann
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Giordano Pula
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Piotr Kuta
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Manuel A. Friese
- Institute for Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf
- Mathias Gelderblom
- Department of Neurology, University Medical Center Hamburg-Eppendorf
- Albert Sickmann
- Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V.
- Roger J. S. Preston
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Jerzy-Roch Nofer
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Stefan Rose-John
- Institute of Biochemistry, University of Kiel
- Lynn M. Butler
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Ophira Salomon
- Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel and Sackler Faculty of Medicine, University of Tel Aviv
- Evi X. Stavrou
- Department of Medicine, Louis Stokes Veterans Administration Medical Center
- Thomas Renné
- Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-021-25888-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.
