Nature Communications (Sep 2022)

Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

  • Brieuc Van Nieuwenhuyse,
  • Dimitri Van der Linden,
  • Olga Chatzis,
  • Cédric Lood,
  • Jeroen Wagemans,
  • Rob Lavigne,
  • Kaat Schroven,
  • Jan Paeshuyse,
  • Catherine de Magnée,
  • Etienne Sokal,
  • Xavier Stéphenne,
  • Isabelle Scheers,
  • Hector Rodriguez-Villalobos,
  • Sarah Djebara,
  • Maya Merabishvili,
  • Patrick Soentjens,
  • Jean-Paul Pirnay

DOI
https://doi.org/10.1038/s41467-022-33294-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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In this study, authors use combinatory bacteriophage-antibiotic therapy, as treatment for extensively drug-resistant Pseudomonas aeruginosa infection in a toddler post liver transplantation. They report on the clinical and microbiological improvement, and present their investigation on how bacterial phage resistance did not result in therapeutic failure.