Correlation of changes of ш-6 polyunsaturated fatty acids and free radical processes in erythrocyte membranes of umbilical cord of newborns with cytomegalovirus infection

Abstract

To examine the correlation of changes of ω-6 polyunsaturated fatty acids and free-radical processes in the blood of the umbilical cord of newborns to mothers with cytomegalovirus infection, the content of ω-6 polyunsaturated arachidonic, linoleic fatty acids, the concentration of the products of reacting with thiobarbituric acid and activity of phospholipase A2 in the membrane of red blood cells of the umbilical cord were studied. The material for the study was the umbilical cord blood of 40 newborns from mothers who had cytomegalovirus infection in the HI trimester (titer of IgG antibodies to cytomegalovirus 1: 1600) - the main group. The control group consisted of 40 infants from healthy women It was found that the aggravation of chronic cytomegalovirus infection in mothers (titer of IgG antibodies to cytomegalovirus infection 1: 1600) contributes to the activation of lipid peroxidation (the repression of antioxidant protection) in the cord blood of newborns, increasing the concentration of TBA-active products on the background of the high activity of phospholipase A (more than 2-fold; p < 0.001) and is associated with the generation of large amounts of precursors of pro-inflammatory eicosanoids acids ω-6 family: linoleic (56 %; p < 0.001) and arachidonic (34 %; p < 0.001). Increase in TBA-active products has a close relation to the content of arachidonic acid in umbilical cord blood of newborns from mothers with cytomegalovirus infection, the correlation coefficient r was 0.78 (p < 0.001). The revealed changes in the membrane of red blood cells from the umbilical cord of newborns from mothers with cytomegalovirus infection may become the adverse gestation factor.

Keywords

• ω-6 линолевая и арахидоновая кислоты
• ω-6 linoleic and arachidonic acids
• lipid peroxidation
• umbilical cord blood
• cytomegalovirus infection