Nature Communications (Dec 2020)
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
- Dohyun Im,
- Asuka Inoue,
- Takaaki Fujiwara,
- Takanori Nakane,
- Yasuaki Yamanaka,
- Tomoko Uemura,
- Chihiro Mori,
- Yuki Shiimura,
- Kanako Terakado Kimura,
- Hidetsugu Asada,
- Norimichi Nomura,
- Tomoyuki Tanaka,
- Ayumi Yamashita,
- Eriko Nango,
- Kensuke Tono,
- Francois Marie Ngako Kadji,
- Junken Aoki,
- So Iwata,
- Tatsuro Shimamura
Affiliations
- Dohyun Im
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Asuka Inoue
- Graduate School of Pharmaceutical Sciences, Tohoku University
- Takaaki Fujiwara
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Takanori Nakane
- Department of Biological Sciences, Graduate School of Science, University of Tokyo
- Yasuaki Yamanaka
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Tomoko Uemura
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Chihiro Mori
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Yuki Shiimura
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Kanako Terakado Kimura
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Hidetsugu Asada
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Norimichi Nomura
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Tomoyuki Tanaka
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Ayumi Yamashita
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Eriko Nango
- RIKEN SPring-8 Center
- Kensuke Tono
- Japan Synchrotron Radiation Research Institute
- Francois Marie Ngako Kadji
- Graduate School of Pharmaceutical Sciences, Tohoku University
- Junken Aoki
- Graduate School of Pharmaceutical Sciences, Tohoku University
- So Iwata
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- Tatsuro Shimamura
- Department of Cell Biology, Graduate School of Medicine, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-020-20221-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing antipsychotics with improved receptor selectivity.
