Nature Communications (Nov 2021)
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions
- Karin Schmelz,
- Joern Toedling,
- Matt Huska,
- Maja C. Cwikla,
- Louisa-Marie Kruetzfeldt,
- Jutta Proba,
- Peter F. Ambros,
- Inge M. Ambros,
- Sengül Boral,
- Marco Lodrini,
- Celine Y. Chen,
- Martin Burkert,
- Dennis Guergen,
- Annabell Szymansky,
- Kathy Astrahantseff,
- Annette Kuenkele,
- Kerstin Haase,
- Matthias Fischer,
- Hedwig E. Deubzer,
- Falk Hertwig,
- Patrick Hundsdoerfer,
- Anton G. Henssen,
- Roland F. Schwarz,
- Johannes H. Schulte,
- Angelika Eggert
Affiliations
- Karin Schmelz
- Charité—Universitätsmedizin Berlin
- Joern Toedling
- Charité—Universitätsmedizin Berlin
- Matt Huska
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Maja C. Cwikla
- Charité—Universitätsmedizin Berlin
- Louisa-Marie Kruetzfeldt
- Charité—Universitätsmedizin Berlin
- Jutta Proba
- Charité—Universitätsmedizin Berlin
- Peter F. Ambros
- Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung
- Inge M. Ambros
- Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung
- Sengül Boral
- Charité—Universitätsmedizin Berlin
- Marco Lodrini
- Charité—Universitätsmedizin Berlin
- Celine Y. Chen
- Charité—Universitätsmedizin Berlin
- Martin Burkert
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Dennis Guergen
- Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO)
- Annabell Szymansky
- Charité—Universitätsmedizin Berlin
- Kathy Astrahantseff
- Charité—Universitätsmedizin Berlin
- Annette Kuenkele
- Charité—Universitätsmedizin Berlin
- Kerstin Haase
- Charité—Universitätsmedizin Berlin
- Matthias Fischer
- Department of Experimental Pediatric Oncology, Medical Faculty, University Children’s Hospital of Cologne
- Hedwig E. Deubzer
- Charité—Universitätsmedizin Berlin
- Falk Hertwig
- Charité—Universitätsmedizin Berlin
- Patrick Hundsdoerfer
- Charité—Universitätsmedizin Berlin
- Anton G. Henssen
- Charité—Universitätsmedizin Berlin
- Roland F. Schwarz
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Johannes H. Schulte
- Charité—Universitätsmedizin Berlin
- Angelika Eggert
- Charité—Universitätsmedizin Berlin
- DOI
- https://doi.org/10.1038/s41467-021-26870-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.
