Dynamical Behaviour of a Modified Tuberculosis Model with Impact of Public Health Education and Hospital Treatment

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis is one of the treacherous infectious diseases of global concern. In this paper, we consider a deterministic model of TB infection with the public health education and hospital treatment impact. The effective reproductive number, Rph, that measures the potential spread of TB is presented by employing the next generation matrix approach. We investigate local and global stability of the TB-free equilibrium point, endemic equilibrium point, and sensitivity analysis. The analyses of the proposed model show that the model undergoes the phenomenon of backward bifurcation when the effective reproduction number (Rph) is less than one, where two stable equilibria, namely, the DFE and an EEP coexist. Further, we compute the sensitivity of the impact of each parameter on the effective reproductive number of the model by employing a normalized sensitivity index formula. Numerical simulation of the proposed model was conducted using Maple 2016 and MatLab R2020b software and compared with the theoretical results for illustration purposes. The investigation results can be useful in providing information to policy makers and public health authorities in mitigating the spread of TB infection by public health education and hospital treatment.

Keywords

• tuberculosis infection
• public health education
• hospital treatment
• effective reproduction number
• stability analysis
• bifurcation analysis