Diagnostic Pathology (Jan 2024)

A rare co-existence of histiocytic necrotizing lymphadenitis with metastatic papillary thyroid carcinoma and review of the literature

  • Jing Liu,
  • Lei Jiang,
  • Guohua Yu,
  • Guimei Qu,
  • Li Cai

DOI
https://doi.org/10.1186/s13000-024-01441-0
Journal volume & issue
Vol. 19, no. 1
pp. 1 – 8

Abstract

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Abstract Histiocytic necrotizing lymphadenitis (HNL) is a benign, self-limiting disease that is rare clinically. The coexistence of HNL and tumor is rarer. We report a male patient who was preoperatively diagnosed with papillary thyroid carcinoma with cervical lymph nodes metastasis, and the postoperative pathological examination showed histiocytic necrotizing lymphadenitis combined with metastatic papillary thyroid carcinoma in the same single lymph node. More interestingly, Epstein‒Barr virus was positive in these lymph nodes by in situ hybridization. This may suggest a trigger for the coexistence of the two diseases.

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