Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

N. O. Alieva; A. K. Efremov; S. Hu; D. Oh; Z. Chen; M. Natarajan; H. T. Ong; A. Jégou; G. Romet-Lemonne; J. T. Groves; M. P. Sheetz; J. Yan; A. D. Bershadsky

doi:10.1038/s41467-019-10964-w

Nature Communications (Aug 2019)

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

N. O. Alieva,
A. K. Efremov,
S. Hu,
D. Oh,
Z. Chen,
M. Natarajan,
H. T. Ong,
A. Jégou,
G. Romet-Lemonne,
J. T. Groves,
M. P. Sheetz,
J. Yan,
A. D. Bershadsky

Affiliations

N. O. Alieva: Mechanobiology Institute, National University of Singapore, T-lab
A. K. Efremov: Mechanobiology Institute, National University of Singapore, T-lab
S. Hu: Mechanobiology Institute, National University of Singapore, T-lab
D. Oh: Mechanobiology Institute, National University of Singapore, T-lab
Z. Chen: Mechanobiology Institute, National University of Singapore, T-lab
M. Natarajan: Mechanobiology Institute, National University of Singapore, T-lab
H. T. Ong: Mechanobiology Institute, National University of Singapore, T-lab
A. Jégou: Institut Jacques Monod, CNRS, Université de Paris
G. Romet-Lemonne: Institut Jacques Monod, CNRS, Université de Paris
J. T. Groves: Mechanobiology Institute, National University of Singapore, T-lab
M. P. Sheetz: Mechanobiology Institute, National University of Singapore, T-lab
J. Yan: Mechanobiology Institute, National University of Singapore, T-lab
A. D. Bershadsky: Mechanobiology Institute, National University of Singapore, T-lab

DOI: https://doi.org/10.1038/s41467-019-10964-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin at the tip to support force transmission through the actin core.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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