Risk factors that determine the severity of bronchial obstruction syndrome of acute respiratory viral infections in children

Abstract

The article deals the possibilities of using early clinical and anamnestic data for the diagnosis of severe bronchial obstruction in children.The aim of the study was to search for informative indicators that affect the severity of bronchial obstruction against the background of acute respiratory viral infections, and to develop a mathematical predictive model for use at the stages of hospitalization.Materials and methods. The study was based on the examination and observation of 386 children aged 1 month to 5 years who were treated in the respiratory department and the intensive care unit with a diagnosis of bronchial obstruction syndrome. To search for informative indicators, 34 anamnestic signs were studied, including those in mother-child pairs. Comparison of indicators was carried out according to Student's t-test for independent samples and у 2 test to assess categorical differences. To assess the effect of each independent variable on the outcomes of interest, variables reaching P ≤ 0.25 in bivariate analysis were included in a multivariate logistic regression model.Results. Mathematical processing showed that only 1 9 factors were identified as significantly influencing the severity of the disease (p < 0.001), while others were not potential determinants of severity. For the main ones, diagnostic values were calculated and a mathematical forecasting model was built with a high level of reliability — 95%.

Keywords

• bronchial obstruction syndrome
• acute respiratory viral infections
• children