SAGE Open Medicine (Apr 2022)
Mother-to-child transmission of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women with single, dual or triplex infections of human immunodeficiency virus, hepatitis B virus and hepatitis C virus in Nigeria: A systematic review and meta-analysis
- George Uchenna Eleje,
- Chinyere Ukamaka Onubogu,
- Preye Owen Fiebai,
- Ikechukwu Innocent Mbachu,
- Godwin Otuodichinma Akaba,
- Olabisi Morebise Loto,
- Hadiza Abdullahi Usman,
- Ayyuba Rabiu,
- Moriam Taiwo Chibuzor,
- Rebecca Chinyelu Chukwuanukwu,
- Ngozi Nneka Joe-Ikechebelu,
- Chike Henry Nwankwo,
- Stephen Okoroafor Kalu,
- Chukwuanugo Nkemakonam Ogbuagu,
- Shirley Nneka Chukwurah,
- Chinwe Elizabeth Uzochukwu,
- Ijeoma Chioma Oppah,
- Aishat Ahmed,
- Richard Obinwanne Egeonu,
- Chiamaka Henrietta Jibuaku,
- Samuel Oluwagbenga Inuyomi,
- Bukola Abimbola Adesoji,
- Ubong Inyang Anyang,
- Uchenna Chukwunonso Ogwaluonye,
- Ekene Agatha Emeka,
- Odion Emmanuel Igue,
- Ogbonna Dennis Okoro,
- Prince Ogbonnia Aja,
- Chiamaka Perpetua Chidozie,
- Hadiza Sani Ibrahim,
- Fatima Ele Aliyu,
- Aisha Ismaila Numan,
- Solace Amechi Omoruyi,
- Osita Samuel Umeononihu,
- Chukwuemeka Chukwubuikem Okoro,
- Ifeanyi Kingsley Nwaeju,
- Arinze Anthony Onwuegbuna,
- Eric Okechukwu Umeh,
- Sussan Ifeyinwa Nweje,
- Lydia Ijeoma Eleje,
- Ifeoma Clara Ajuba,
- David Chibuike Ikwuka,
- Emeka Philip Igbodike,
- Chisom God’swill Chigbo,
- Uzoamaka Rufina Ebubedike,
- Chigozie Geoffrey Okafor,
- Nnaedozie Paul Obiegbu,
- Ibrahim Adamu Yakasai,
- Oliver Chukwujekwu Ezechi,
- Joseph Ifeanyichukwu Ikechebelu,
Affiliations
- George Uchenna Eleje
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Chinyere Ukamaka Onubogu
- Department of Paediatrics, Nnamdi Azikiwe University, Awka, Nigeria
- Preye Owen Fiebai
- Department of Obstetrics and Gynecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
- Ikechukwu Innocent Mbachu
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Godwin Otuodichinma Akaba
- Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja, Nigeria
- Olabisi Morebise Loto
- Department of Obstetrics and Gynecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
- Hadiza Abdullahi Usman
- Department of Obstetrics and Gynecology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
- Ayyuba Rabiu
- Department of Obstetrics and Gynecology, Aminu Kano Teaching Hospital, Kano, Nigeria
- Moriam Taiwo Chibuzor
- Cochrane Nigeria, Institute of Tropical Diseases Research and Prevention, University of Calabar Teaching Hospital, Calabar, Nigeria
- Rebecca Chinyelu Chukwuanukwu
- Immunology Unit, Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria
- Ngozi Nneka Joe-Ikechebelu
- Department of Community Medicine and Primary Health Care, Faculty of Medicine, Chukwuemeka Odumegwu Ojukwu University, Awka, Nigeria
- Chike Henry Nwankwo
- Department of Statistics, Nnamdi Azikiwe University, Awka, Nigeria
- Stephen Okoroafor Kalu
- HIV Care Laboratory/HIV Care Department, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Chukwuanugo Nkemakonam Ogbuagu
- Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
- Shirley Nneka Chukwurah
- Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
- Chinwe Elizabeth Uzochukwu
- Department of Mass Communication, Nnamdi Azikiwe University, Awka, Nigeria
- Ijeoma Chioma Oppah
- Department of Obstetrics and Gynecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
- Aishat Ahmed
- Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja, Nigeria
- Richard Obinwanne Egeonu
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Chiamaka Henrietta Jibuaku
- Department of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria
- Samuel Oluwagbenga Inuyomi
- Department of Physics and Engineering Physics, Obafemi Awolowo University, Ile-Ife, Nigeria
- Bukola Abimbola Adesoji
- Department of Nursing, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
- Ubong Inyang Anyang
- Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja, Nigeria
- Uchenna Chukwunonso Ogwaluonye
- Department of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria
- Ekene Agatha Emeka
- Department of Family Medicine, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
- Odion Emmanuel Igue
- Department of Physiological Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
- Ogbonna Dennis Okoro
- Department of Parasitology & Entomology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
- Prince Ogbonnia Aja
- Immunology Unit, Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria
- Chiamaka Perpetua Chidozie
- Immunology Unit, Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria
- Hadiza Sani Ibrahim
- Department of Obstetrics and Gynecology, Aminu Kano Teaching Hospital, Kano, Nigeria
- Fatima Ele Aliyu
- Department of Obstetrics and Gynecology, Aminu Kano Teaching Hospital, Kano, Nigeria
- Aisha Ismaila Numan
- Department of Obstetrics and Gynecology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
- Solace Amechi Omoruyi
- Department of Obstetrics and Gynecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
- Osita Samuel Umeononihu
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Chukwuemeka Chukwubuikem Okoro
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Ifeanyi Kingsley Nwaeju
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Arinze Anthony Onwuegbuna
- Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Nigeria
- Eric Okechukwu Umeh
- Department of Radiology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
- Sussan Ifeyinwa Nweje
- Department of Nursing, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Lydia Ijeoma Eleje
- Measurement, Evaluation and Research Unit, Department of Educational Foundations, Nnamdi Azikiwe University, Awka, Nigeria
- Ifeoma Clara Ajuba
- Department of Hematology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
- David Chibuike Ikwuka
- Department of Human Physiology, Nnamdi Azikiwe University, Awka, Nigeria
- Emeka Philip Igbodike
- Department of Obstetrics and Gynecology, St Georges Hospital Memorial Centre, Lagos, Nigeria
- Chisom God’swill Chigbo
- Department of Applied Microbiology, Nnamdi Azikiwe University, Awka, Nigeria
- Uzoamaka Rufina Ebubedike
- Department of Radiology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
- Chigozie Geoffrey Okafor
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Nnaedozie Paul Obiegbu
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- Ibrahim Adamu Yakasai
- Department of Obstetrics and Gynecology, Aminu Kano Teaching Hospital, Kano, Nigeria
- Oliver Chukwujekwu Ezechi
- Nigerian Institute of Medical Research, Yaba, Nigeria
- Joseph Ifeanyichukwu Ikechebelu
- Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria
- DOI
- https://doi.org/10.1177/20503121221095411
- Journal volume & issue
-
Vol. 10
Abstract
Objectives: To systematically review literature and identify mother-to-child transmission rates of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among pregnant women with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria. PRISMA guidelines were employed. Searches were on 19 February 2021 in PubMed, Google Scholar and CINAHL on studies published from 1 February 2001 to 31 January 2021 using keywords: “MTCT,” “dual infection,” “triplex infection,” “HIV,” “HBV,” and “HCV.” Studies that reported mother-to-child transmission rate of at least any of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women and their infant pairs with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria irrespective of publication status or language were eligible. Data were extracted independently by two authors with disagreements resolved by a third author. Meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce summary mother-to-child transmission rates in terms of percentage with 95% confidence interval. Protocol was prospectively registered in PROSPERO: CRD42020202070. The search identified 849 reports. After screening titles and abstracts, 25 full-text articles were assessed for eligibility and 18 were included for meta-analysis. We identified one ongoing study. Pooled mother-to-child transmission rates were 2.74% (95% confidence interval: 2.48%–2.99%; 5863 participants; 15 studies) and 55.49% (95% confidence interval: 35.93%–75.04%; 433 participants; three studies), among mother–infant pairs with mono-infection of human immunodeficiency virus and hepatitis B virus, respectively, according to meta-analysis. Overall, the studies showed a moderate risk of bias. The pooled rate of mother-to-child transmission of human immunodeficiency virus was 2.74% and hepatitis B virus was 55.49% among mother–infant pairs with mono-infection of HIV and hepatitis B virus, respectively. No data exists on rates of mother-to-child transmission of hepatitis C virus on mono-infection or mother-to-child transmission of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among mother–infant pairs with dual or triplex infection of HIV, hepatitis B virus and HCV in Nigeria.
